Table 4 Activity and efficacy analyses summary

From: Raltitrexed–eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer

 

Best response

Outcome measures

Previous treatment

PR

SD

PFS-6

OS-12

All patients (n=41)

10 (24.4%)

11 (26.8%)

6 (14.6%)

5 (12.2%)

PEFG (n=16)

3 (18.7%)

6 (37.5%)

3 (18.8%)

4 (25.0%)

G (n=17)

5 (29.4%)

4 (23.5%)

2 (11.8%)

0 (0.0%)

G → PEFG (=5)

0 (0.0%)

1 (20.0%)

0 (0.0%)

0 (0.0%)

F including

 y (n=23)

5 (21.7%)

7 (30.4%)

4 (17.4%)

5 (21.7%)

 n (n=18)

5 (27.8%)

4 (22.2%)

2 (11.8%)

0 (0.0%)

P including

 y (n=22)

3 (13.6%)

7 (31.8%)

3 (13.6%)

4 (18.2%)

 n (n=19)

7 (36.8%)

4 (21.1%)

3 (15.8%)

1 (5.3%)

n of lines

 1 (n=35)

9 (25.7%)

10 (28.6%)

6 (17.1%)

5 (14.3%)

 >1 (n=6)

1 (16.6%)

1 (16.6%)

0 (0.0%)

0 (0.0%)

  1. n=number; PR=partial response; SD=stable disease; PFS-6=progression-free at 6 months; OS-12=alive at 12 months; P=cisplatin; E=epirubicin; F=5-fluorouracil; G=gemcitabine; y=yes; n=no; → =followed by.