Table 6 Results of salvage therapy for pancreatic adenocarcinoma

From: Raltitrexed–eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer

Ref

No. of pts

Treatment

m. age

PS 0

M (%)

liver M (%)

>1CHT (%)

PPFS

ORR (%)

mPFS

PFS-6 (%)

1 year OS (%)

7

30

I+E

60

30

100

60

23

Nr

10

4.1

Nr

23

15a

34

G-FLIP

64

Nr

100

85

29

Nr

24

3.9

20

20

17

17

F+celecoxib

60

35

82

Nr

0

Nr

35

1.9

6

20

21

18

T

59

Nr

100

Nr

22

7.9

5.5

3.3

Nr

Nr

26

15

MDI

61

26

100

60

20

Nr

0

1.7

0

0

29

33

Ru

62

0

73

57

Nr

Nr

9

Nr

Nr

6

30

19

R

60

21

100

74

0

Nr

0

2.5

Nr

0

30

19

R+I

63

21

100

63

0

Nr

16

4.0

Nr

22

cs

41

R+E

61

61

100

80

15

6.0

24

1.8

15

12

  1. Ref=reference; No. of pts=number of patients; m. age=median age; PS 0=performance status=0 (ECOG) or 90–100 (Karnofsky); M=metastatic; CHT=% of patients with >1 previous chemotherapy lines; PPFS=previous progression-free survival; ORR=objective response rate; m PFS=median progression-free survival; PFS-6=progression-free survival at 6 months; 1 year OS=overall survival at 1 year; cs=current series; I=irinotecan; E=eloxatin; G=gemcitabine; F=5-fluorouracil; L=leucovorin; P=cisplatin; T=paclitaxel; M=mitomycin; D=docetaxel; Ru=rubitecan; R=raltitrexed; Nr=not reported.
  2. aRetrospective.