Figure 2

Progesterone receptor expression in normal breast epithelium taken from women at population risk of breast cancer, those at high risk and those carrying BRCA1 and BRCA2 mutations, which had been implanted into athymic nude mice and treated for 1 week with control, (A), 0.5 mg E₂ (B) or 2.0 mg E₂ (C)-silastic pellets. The thick horizontal lines indicate the median values as do the figures above the columns indicating the IQRs. The numbers in parentheses are the numbers of samples available for analysis in each group and the P-values indicate the significance of the differences across the risk groups by Kruskal–Wallis nonparametric analysis of variance. PgR=progesterone receptor; PR=population risk; HR=high risk; All muts=all mutations; BRCA1 only=BRCA1 mutation carriers only.