Table 1 Characteristics of patients (n=75), surgery and chemotherapy
Characteristic | No. of patients | % |
|---|---|---|
Patient characteristics | ||
Gender | ||
Female | 17 | 23 |
Male | 58 | 77 |
Age (years); median (range) | 59 (39–76) | |
Performance status | ||
0 | 45 | 60 |
1 | 28 | 37 |
2 | 2 | 3 |
Number of pack-years; median (range) | 45 (9–160) | |
Smoking habits | ||
Continued | 31 | 41 |
Stopped | 37 | 49 |
Never smoked | 7 | 10 |
Serum LDH (× ULN); median (range) | 0.77 (0.54–3.56) | |
>1 × ULN | 14 | 19 |
Tumour characteristics | ||
Initial histology (pathologist from participating centres) | ||
Squamous cell carcinoma | 32 | 43 |
Adenocarcinoma | 23 | 31 |
Large cell carcinoma | 9 | 12 |
Poorly differentiated NSCLC | 11 | 14 |
Tumour stage | ||
1 | 6 | 8 |
2 | 44 | 59 |
3 | 25 | 33 |
Mediastinal lymph node enlargement (>1 cm) by CT scan | ||
Yes | 61 | 81 |
No | 14 | 19 |
Tumour localisation | ||
Upper lobe right | 31 | 42 |
Middle lobe right | 3 | 4 |
Lower lobe right | 9 | 12 |
Upper lobe left | 11 | 15 |
Lower lobe left | 1 | 1 |
Central right | 10 | 13 |
Central left | 10 | 13 |
Characteristics of the surgery | ||
Type of resection: | ||
Lobectomy/bilobectomy | 28/10 | 37/13 |
Pneumonectomy (right/left) | 21/16 | 28/22 |
Complete resectiona | ||
Yes | 43 | 57 |
No | 32 | 43 |
Radical resection of the primary tumour: | ||
Negative margin | 63 | 84 |
Positive margin | 12 | 16 |
Activity of the chemotherapy | ||
Response after neoadjuvant chemotherapy | ||
CR | 7 | 9 |
PR | 48 | 64 |
NC | 20 | 27 |
Pathological response on primary tumour (% of necrosis and fibrosis, two missing) | ||
Median (range) | 60% (0–100%) | |
⩾90% | 20 | 27 |
<20% | 12 | 16 |
Downstaging of mediastinal lymph nodes (four missing) | ||
N0 | 23 | 32 |
N1 | 22 | 31 |
N2 | 26 | 37 |
