Table 2 FISH analysis of RET rearrangements in 14 post-Chernobyl PTCs with a short latency

From: RET rearrangements in post-Chernobyl papillary thyroid carcinomas with a short latency analysed by interphase FISH

   

Tumour tissue

  

Case

Latency in years/gender a

Histological variant

Aberrant cells (%)

Normal cells (%)

Nonhomogeneous distribution of FISH signals b

Tumour cell contentc (%)

I

6.58/F

Follicular/solid

13

87

—

>95

II

8.21/F

Papillary

55

45

—

>95

III

8.06/F

Papillary

6

94

—

>95

IV

5.67/F

Papillary

23

77

—

>95

V

8.18/F

Papillary/follicular

15

85

—

>95d

VI

8.12/F

Papillary

6

94

—

>95

VII

7.61/F

Solid

13

87

Yes

>95

VIII

7.10/F

Solid

11

89

—

>95d

IX

7.62/M

Solid

24

76

—

>95

X

8.0/F

Solid

14

86

—

>95d

XI

6.85/F

Solid

29

71

—

>95d

XII

6.72/M

Follicular

11

89

—

>95

XIII

6.71/F

Follicular

4

96

—

>95d

  1. aYears/F=female; FISH=fluorescent in situ hybridisation; M=male.
  2. bBinominal homogeneity test to calculate a dispersion factor. P<0.05 indicates a nonhomogeneous distribution of aberrant cells between all viewing areas scored.
  3. cThe percentage of tumour cells was evaluated from microdissected tissue sections after FISH analysis and after staining with haematoxylin (see also Figure 1).
  4. dSporadic entrapped non-neoplastic follicles were present (<1–2%).
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