Table 1 Gene expression profile using Affymetrix arrays of genes differentially expressed in MET1 and MET4 vs PM1cell line and MET1 vs MET4.

From: Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours

			MET1 vs PM1	MET4 vs PM1	MET1 vs MET4
Genbank	Common	Function	Fold +/−	Fold +/−	Fold +/−
Ubiquitin cycle/proteolysis and peptidolysis
AA020826	CTSB	Cathepsin B		−5
		Transport
N74607	AQP3	Aquaporin 3	−10	−6
AF201942	NXT2	Nuclear transport factor 2-like export factor 2			8
Transcription/replication
NM_004364	CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	−10
H94842	HOXA11	Homeo box A11	6	8
BC005342	NSBP1	Nucleosomal-binding protein 1	16
NM_016594	FKBP11	FK506-binding protein 11, 19 kDa	5
AB046692	AOX1	Aldehyde oxidase 1		8
Signalling
NM_006176	NRGN	Neurogranin (protein kinase C substrate, RC3)			11
NM_001945	DTR	Diphtheria toxin receptor)	16	22
AA464753	PDAP1	Homo sapiens, clone IMAGE:3457786		−8
M14333	FYN	FYN oncogene related to SRC, FGR, YES	5
NM_004335	BST2	Bone marrow stromal cell antigen 2			16
NM_013447	EMR2	egf-like, hormone receptor-like sequence 2			−6
NM_003020	SGNE1	Secretory granule, neuroendocrine protein 1
(7B2 protein)		5
AI439556	TXNIP	Thioredoxin interacting protein		−5
Development
NM_000366	TPM1	Tropomyosin 1 (alpha)			6
NM_003412	ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	33	39
U61276	JAG1	Jagged 1 (Alagille syndrome)		5
NM_014556	EVC	Ellis van Creveld syndrome			10
Growth factor/chemokine/cytokine/inflammation/immune response
NM_002658	PLAU	Plasminogen activator, urokinase	6
AL573058	C1R	Complement component 1, r subcomponent	13	10
M92934	CTGF	Connective tissue growth factor			13
NM_003596	TPST1	Tyrosylprotein sulfotransferase 1	8
NM_013314	BLNK	B-cell linker		6
NM_002964	S100A8	S100 calcium-binding protein A8 (calgranulin A)	5
NM_002852	PTX3	Pentaxin-related gene, rapidly induced by IL-1 beta	8
M69176	CEACAM1	Carcinoembryonic antigen-related cell adhesion molecule 1	6
NM_006379	SEMA3C	Semaphorin 3C	10
NM_002053	GBP1	Guanylate-binding protein 1, interferon-inducible, 67 kDa	7
NM_014391	ANKRD1	Cardiac ankyrin repeat protein	−8
NM_000963	PTGS2	Prostaglandin-endoperoxide synthase 2	5	16
L27624	TFPI2	Tissue factor pathway inhibitor 2		9
BG166705	CXCL5	Chemokine (C-X-C motif) ligand 5		227
Cell cycle/oncogene/tumour suppressor
NM_001759	CCND2	Cyclin D2		−7	8
M15329	IL1A	Interleukin 1, alpha	5
NM_005504	BCAT1	Branched chain aminotransferase 1, cytosolic	11
NM_000393	COL5A2	Collagen, type V, alpha 2	44	23
NM_000584	IL8	Interleukin 8	112	32
Metabolism/stress response
NM_005965	MYLK	Myosin, light polypeptide kinase		−7	7
NM_016816	OAS1	2′,5′-oligoadenylate synthetase 1, 40/46 kDa	5
AW614435	UROD	Uroporphyrinogen decarboxylase	16
AV704962	SC4MOL	Sterol-C4-methyl oxidase-like		7
NM_004265	FADS2	Fatty acid desaturase 2	4	5
NM_018192	LEPREL1	Leprecan-like 1	10	15
NM_007034	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4			5
AF054841	TM4SF7	Transmembrane 4 superfamily member 7	−5	−6
NM_000050	ASS	Argininosuccinate synthetase		−5
Cytoskeleton/cell adhesion
NM_002628	PFN2	Profilin 2	25	15
U76549	KRT8	Keratin 8		−6
AI831452	KRT6B	Keratin 6B			5
NM_004791	ITGBL1	Integrin, beta-like 1 (with EGF-like repeat domains)	7		15
AI806793	COL8A2	Collagen, type VIII, alpha 2			8
AI922599	VIM	Vimentin	5
NM_000422	KRT17	Keratin 17	−5
Apoptosis
NM_006290	TNFAIP3	Tumor necrosis factor, alpha-induced protein 3	7
BG260394	SNCA	Synuclein, alpha	8	5
Receptor
NM_021913	AXL	AXL receptor tyrosine kinase	12
NM_000142	FGFR3	Fibroblast growth factor receptor 3		−35
Others
NM_000104	CYP1B1	Cytochrome P450, subfamily I			−7
NM_003118	SPARC	Secreted protein, acidic, cysteine-rich (osteonectin)		−7
NM_007150	ZNF185	Zinc finger protein 185 (LIM domain)		5
BF213279	FARP1	FERM, RhoGEF (ARHGEF) pleckstrin domain protein 1	−8
NM_014903	NAV3	Neuron navigator 3	21	18
M58026	CALML3	Calmodulin-like 3		−11
BF217861	MT1E	Metallothionein 1E	15	23
NM_020672	S100A14	S100 calcium-binding protein A14	−7	−12
NM_024593	FLJ11767	Hypothetical protein FLJ11767	−6
NM_000396	CTSK	Cathepsin K (pycnodysostosis)	10	7
NM_016081	KIAA0992	Palladin	6
NM_005785	RNF41	Hypothetical SBBI03 protein		6
NM_004900	APOBEC3B	Apolipoprotein B	8	7
AF088867	AGR2	Anterior gradient 2 homolog (Xenepus laevis)	32	88
AF010316	PTGES	Prostaglandin E synthase	−7		−6
NM_002281	KRTHB1	Keratin, hair, basic, 1		−17
U10691	MAGEA3	Melanoma antigen, family A, 6			−11
AU145365	—	Clone HEMBA1004629, mRNA sequence		7
AK025430	—	Hypothetical protein FLJ21777		−5
NM_024554	PGBD5	Piggybac transposable element derived 5	−31
NM_018436	ALLC	Allantoicase			5
NM_025143	C21orf96	Hypothetical protein FLJ20856		5
W72694	LOC51063	Hypothetical protein LOC51063		−8

Only genes whose expression changed by five-fold or more and P-value of 0.001 or less are listed.

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Table 1 Gene expression profile using Affymetrix arrays of genes differentially expressed in MET1 and MET4 vs PM1cell line and MET1 vs MET4.

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