Table 2 FGFR4 protein expression and clinical/pathological variables
FGFR4 expression | Yes (%) | No (%) | P -value |
|---|---|---|---|
Patients n=137 | n=61 (45) | n=76 (55) | |
Median age (years) | 70 | 62 | |
Age at diagnosis (years) | |||
⩽55 | 14 (23) | 25 (33) | NS |
>55 | 47 (77) | 51 (67) | |
Sex | |||
Male | 33 (24) | 42 (31) | NS |
Female | 28 (20) | 34 (25) | |
Localisation of tumour | |||
Extremities | 29 (21) | 55 (40) | NS |
Trunk, head/neck | 27 (20) | 26 (19) | |
Staining intensity | |||
Minimal | 6 (10) | NS | |
Intermediate | 51 (83) | ||
Strong | 4 (7) | ||
Positively stained cells per tumour | |||
1–9% | 10 (16) | NS | |
10–49% | 21 (34) | ||
50–99% | 10 (16) | ||
100% | 20 (34) | ||
Microvessel density (n=137) | |||
Low | 24 (18) | 57 (42) | 0.001 |
Medium | 21 (15) | 12 (9) | |
High | 15 (11) | 8 (6) | |
CD-31 (meana; n=17) | 44 | 28 | |
Ki-67 (meanb; n=17) | 24 | 14.5 | |
pTNM UICC staging (n=137) | |||
Ia | 15 (11) | 23 (17) | NS |
Ib | 4 (3) | 11 (8) | (0.023 when stages III+ |
IIa | 8 (6) | 12 (9) | |
IIb | 3 (2) | 5 (4) | IV compared to I+II) |
IIIa | 11 (8) | 12 (9) | |
IIIb | 5 (4) | 5 (4) | |
IV | 15 (11) | 8 (6) | |
pTNM AJCC staging (n=137) | |||
Ia | 13 (9) | 24 (18) | NS |
Ib | 6 (4) | 10 (7) | (0.046 when stages III+IV compared to I+II) |
IIa | 3 (2) | 8 (6) | |
IIb | 5 (4) | 8 (6) | |
IIc | 3 (2) | 2 (1) | |
IIIa | 5 (4) | 6 (4) | |
IIIb | 8 (6) | 9 (7) | |
IIIc | 3 (2) | 2 (1) | |
IV | 14 (10) | 8 (6) | |
Tumour thickness Breslow | |||
⩽1 mm | 27 (20) | 32 (23) | NS |
>1 mm | 34 (25) | 44 (32) | |
Clark level | |||
I | 0 | 0 | NS |
II | 14 (10) | 14 (10) | |
III | 18 (13) | 28 (20) | |
IV | 26 (19) | 30 (22) | |
V | 3 (2) | 4 (3) | |
Ulceration (n=137) | |||
Yes | 27 (20) | 18 (13) | 0.009 |
No | 33 (24) | 59 (43) | |
No. of primary tumours | |||
1 | 39 (28) | 64 (47) | 0.022 |
>1 | 22 (16) | 12 (9) | |
Metastasis | |||
Yes | 31 (23) | 25 (18) | 0.025 |
No | 30 (22) | 51 (37) | |
No. of metastases | |||
1 | 13 (23) | 12 (22) | NS |
>1 | 18 (32) | 13 (23) | |
Subtype of metastasis | |||
Local | 11 (36) | 12 (48) | NS |
Regional | 5 (16) | 5 (20) | |
Distant | 15 (48) | 8 (32) | |
Tumour subtype | |||
SSM | 30 (22) | 37 (27) | NS |
NMM | 25 (18) | 25 (18) | |
Others | 6 (5) | 14 (10) | |
