Figure 1 | British Journal of Cancer

Figure 1

From: Different susceptibility of osteosarcoma cell lines and primary cells to treatment with oncolytic adenovirus and doxorubicin or cisplatin

Figure 1

The oncolytic effect of Ad5-Δ24RGD in combination with doxorubicin or cisplatin on OS cell lines. Three OS cell lines (SaOs-2, MG-63 and U2OS) were incubated at a concentration range of 0.063 to 4-times the average IC50 of each treatment agent. (A) Left panels represent cytotoxicity on OS cell lines of Ad5-Δ24RGD (open diamonds), doxorubicin (open squares) as single agents or the combination of both (closed triangles). Right panels represent cytotoxicity obtained with Ad5-Δ24RGD (open diamonds), cisplatin (open squares) or the combination (closed triangles). Cell survival was expressed relative to nontreated controls. Data represent a typical experiment performed in triplicate. (B) Results from the combination experiments were analysed by the CalcuSyn program. Data shown are mean CI values with s.d. from three independent experiments each performed in triplicate. CI values below 0.9 were defined as synergistic, between 0.9 and 1.1 as additive and above 1.1 as antagonistic.

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