Table 2 First-line chemotherapy

LV5FU2: folinic acid 200 mg sqm day⁻¹ 2 h infusion; 5FU 400 mg sqm day⁻¹ bolus; 5FU 600 mg sqm day⁻¹ 22 h infusion d1-2q14d
FOLFOX2: oxaliplatin 100 mg sqm⁻¹ d1; folinic acid 300 mg sqm day⁻¹ in 2 h infusion; 5FU 1500–1800 mg sqm day⁻¹ in 22 h infusion d1-2q14d
FOLFOX4: oxaliplatin 85 mg sqm⁻¹ d1; folinic acid 200 mg sqm day⁻¹ 2 h infusion; 5FU 400 mg sqm day⁻¹ bolus; 5FU 600 mg sqm day⁻¹ 22 h infusion d1-2q14d
FOLFOX6: oxaliplatin 100 mg sqm d1; folinic acid 200 mg sqm⁻¹ 2 h infusion; 5FU 400 mg sqm⁻¹ bolus; 5FU 2400–3000 mg sqm⁻¹ 46 h infusion
FOLFIRI: irinotecan 180 mg sqm⁻¹ d1; folinic acid 200 mg sqm day⁻¹ 2 h infusion; 5FU 400 mg sqm day⁻¹ bolus; 5FU 600 mg sqm day⁻¹ 22 h infusion d1-2q14d
Chronomodulated FF: folinic acid 300 mg sqm day⁻¹; 5FU 700–1000 mg sqm day⁻¹ d1-4q14d
Chronomodulated FFL: oxaliplatin 25 mg sqm day⁻¹; folinic acid 300 mg sqm day⁻¹; 5FU 700–1000 mg sqm day⁻¹ d1-4q14d.

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