Table 4 Correlation between expression levels of biomarker CEA, CEACAM7-2, CK20 and MUC2 mRNAs in lymph nodes of CRC patients and controls

From: Biomarker selection for detection of occult tumour cells in lymph nodes of colorectal cancer patients using real-time quantitative RT–PCR

 

All lymph nodes

Controls

Dukes' A

Dukes' B

Dukes' C

Dukes' D

Compared mRNA species

r a

P -value a

r

P -value

r

P -value

r

P -value

r

P -value

r

P -value

CEA vs CK20

0.76

<0.0001

0.47

0.005

0.80

0.005

0.58

<0.0001

0.70

0.004

0.76

0.0006

MUC2 vs CK20

0.62

<0.0001

0.50

0.004

0.62

0.04

0.45

0.001

0.69

0.007

0.60

0.05

CEA vs MUC2

0.71

<0.0001

0.33

NS

0.60

NS

0.55

<0.0001

0.78

0.0006

0.80

0.003

CEA vs CEACAM7-2

0.62

<0.0001

0.64

<0.0001

0.42

NS

0.40

0.004

0.54

0.03

0.89

0.0003

CEACAM7-2 vs CK20

0.47

<0.0001

0.53

0.001

0.37

NS

0.16

NS

0.52

0.05

0.85

0.002

CEACAM7-2 vs MUC2

0.55

<0.0001

0.43

0.02

0.44

NS

0.43

0.003

0.41

NS

0.80

0.005

  1. ar- and P-values obtained by pair-wise comparing the expression levels of the indicated mRNA species in lymph nodes of CRC patients and controls using two-tailed Spearman rank correlation test. Numbers of lymph nodes in the analysis were 120–129 for all lymph nodes, 33–34 for controls, 10–11 for Dukes' A patients, 48–52 for Dukes' B patients, 15–16 for Dukes' C patients and 12–16 for Dukes' D patients. NS=not significant, P-value>0.05.
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