Table 2 Correlation between VEGF-C and VEGFR-3 mRNA expression and clinicopathological factor

From: The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer

Clinicopathological factors

No. of patients

VEGF-C

P -value

VEGFR-3

P -value

Age

 70>

40

50.8±58.3

0.15

70.8±128.2

0.07

 70

34

33.6±41.5

 

31.3±38.0

 

Gender

 Male

54

41.2±49.1

0.64

35.4±53.4

0.1

 Female

20

47.5±59.3

 

99.3±163.3

 

T

 1

28

51.7±62.3

0.17

85.9±148.9

0.09

 2

32

32.5±44.8

 

34.4±43.7

 

N

 (−)

48

50.6±57.0

0.08

71.7±118.2

0.003

 (+)

26

28.7±37.0

 

17.5±21.6

 

Stage

 I, II

51

48.3±57.5

0.11

66.1±116.1

0.08

 III, IV

23

31.0±33.6

 

22.9±25.0

 

Histological type

 Adenocarcinoma

39

56.6±60.4

0.006

81.3±126.8

0.003

 Squamous cell ca

32

24.5±33.1

 

15.3±24.4

 

Differentiation

 Adenocarcinoma

Well

16

53.0±55.3

0.76

120.2±177.3

0.11

Mod or Poor

23

59.1±64.8

 

35.9±54.1

 

Squamous cell ca

Well

6

26.4±38.7

0.88

18.3±19.5

0.75

Mod or Poor

26

24.0±32.6

 

14.7±25.7

 
  1. VEGF-C: vascular endothelial growth factor-C;
  2. VEGFR-3: vascular endothelial growth factor receptor-3.