Table 1 Summary of frequently used bolus and infusional 5-FU/FA regimens
From: Management of advanced colorectal cancer: state of the art
Regimens | Doses and schedules of administration |
|---|---|
Mayo Clinic Regimen (Saltz et al, 2000) | 5-FU (425 mg m−2 day−1) i.v. bolus+FA (20 mg m−2 day−1) daily days 1–5 every 4 weeks |
Saltz (modified Roswell Park regimen) (Saltz et al, 2000) | 5-FU (500 mg m−2 day−1) i.v. bolus+FA (20 mg m−2 day−1) weekly for 4 weeks every 6 weeks |
De Gramont (de Gramont et al, 1997) | FA (200 mg m−2) 2 h+5-FU (400 mg m−2) i.v. bolus+22 h infusion 5-FU (600 mg m−2) for 2 consecutive days every 2 weeks |
Modified de Gramont (Leonard et al, 2002) | FA (175–200 mg m−2) 2 h+5-FU (400 mg m−2) i.v. bolus+46 h infusion 5-FU (2400–3000 mg m−2) for 2 consecutive days every 2 weeks |
AIO (Köhne et al, 2005) | 5-FU (2600 mg m−2) 24 h CI+FA (500 mg m−2), weekly × 6, every 7 or 8 weeks |
