Table 1 Numbers of cases and controls, GRR and empirical 95% CI from the population-based study in Scotland: data from the original report, the replication study and from the combined dataa

From: Association of MUTYH and colorectal cancer

 

Farrington et al (2005) ( P =0.001)

Replication ( P =0.09)

All together ( P =0.0006)

Genotype

No. of cases/controls

GRR (95% CI)

No. of cases/controls

GRR (95% CI)

No. of cases/controls

GRR (95% CI)

MM

12/0

93.6 (42.6–213.2)

5/0

38.5 (10.6–110.1)

17/0

67.3 (35.3–128.7)

WM

45/28

1.4 (0.9–2.1)

18/20

0.8 (0.5–1.4)

63/48

1.13 (0.8–1.5)

WW

2160/1794

1.0

905/825

1.0

3065/2619

1.0

Total

2217/1822

 

928/845

 

3145/2667

 
  1. GRR is the genotype relative risk, CI is the confidence interval and P is the significance level for the test of association using a χ2 test with 2 degrees of freedom.
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