Table 3 Health related quality of life, SF-36 scoresa: mean (s.d.)

From: Genetic nurse counsellors can be an acceptable and cost-effective alternative to clinical geneticists for breast cancer risk genetic counselling. Evidence from two parallel randomised controlled equivalence trials

 

Grampian

Wales

Time

Nurse counsellor

Geneticist

Difference (95% CI) b

Nurse counsellor

Geneticist

Difference (95% CI) b

Physical functioning

 Baseline

88.9 (18.6)

85.4 (21.8)

 

83.5 (21.8)

88.9 (18.3)

 

 FU1

88.2 (19.1)

88.6 (18.7)

−0.5 (−3.3 to 2.2)

84.9 (20.9)

88.0 (22.5)

0.3 (−3.7 to 4.3)

 FU2

87.9 (18.5)

86.4 (21.3)

0.2 (−2.3 to 2.7)

84.6 (21.3)

88.6 (20.1)

−0.5 (−5.5 to 4.5)

Social functioning

 Baseline

84.0 (23.4)

84.6 (22.1)

 

77.7 (24.4)

79.8 (26.2)

 

 FU1

83.4 (23.9)

85.2 (21.2)

−0.6 (−5.7 to 4.5)

78.9 (24.8)

79.9 (25.4)

0.3 (−4.9 to 5.4)

 FU2

84.7 (21.8)

87.2 (23.2)

−1.0 (−6.4 to 4.4)

78.0 (26.9)

80.1 (26.4)

−1.0 (−7.6 to 5.5)

Role physical

 Baseline

87.1 (29.0)

86.1 (31.3)

 

81.6 (33.5)

84.9 (30.9)

 

 FU1

86.8 (30.2)

85.1 (32.6)

5.1 (−1.6 to 11.8)c

77.4 (37.7)

82.7 (33.4)

−3.9 (−11.4 to 3.6)

 FU2

86.0 (30.9)

87.1 (30.3)

1.3 (−6.1 to 8.7)

77.5 (37.9)

74.0 (38.7)

5.5 (−4.3 to 15.4)

Vitality

 Baseline

58.6 (21.3)

58.5 (23.3)

 

53.6 (21.1)

54.9 (21.3)

 

 FU1

60.8 (21.7)

61.7 (19.4)

0.5 (−3.7 to 4.7)

57.1 (22.3)

55.7 (20.3)

2.0 (−2.3 to 6.3)

 FU2

61.6 (20.7)

63.9 (19.0)

−1.4 (−5.7 to 2.9)

55.3 (22.5)

58.3 (21.1)

−1.8 (−7.0 to 3.4)

Bodily pain

 Baseline

76.3 (23.9)

76.6 (25.1)

 

72.3 (25.4)

75.5 (25.0)

 

 FU1

78.6 (24.7)

77.4 (24.4)

2.3 (−2.4 to 7.1)

75.8 (24.6)

75.8 (26.0)

−0.2 (−5.3 to 4.9)

 FU2

78.2 (24.5)

76.1 (23.8)

1.7 (−3.8 to 7.2)

74.9 (24.9)

75.2 (19.4)

−0.2 (−6.8 to 6.4)

General health

 Baseline

73.5 (19.8)

73.4 (18.9)

 

66.0 (20.6)

71.2 (20.0)

 

 FU1

75.2 (20.7)

74.9 (18.4)

0.8 (−2.5 to 4.0)

67.9 (21.4)

69.9 (20.7)

1.0 (−2.4 to 4.3)

 FU2

75.0 (18.6)

73.7 (18.5)

1.7 (−2.0 to 5.4)

68.6 (21.5)

72.5 (19.4)

−0.03 (−3.9 to 3.8)

  1. Higher score indicates better health state (range 0–100).
  2. bAdjusted for baseline.
  3. cLarger than expected difference due to baseline imbalance of responders at FU1.