Table 1 Updated DLT probabilities of the five tested dose levels, computed after each newly included cohort of three patients per dose level through the use of Bayes theorem

HHT-loading dose (mg m⁻² day⁻¹)

Initial guesses of toxicity probability

0.5

1

3

5

6

Updated estimated probability of DLT

Administrated dose (mg m⁻² day⁻¹)

Clinical response

0.5

0.1

0.15

0.33

0.50