Table 2b Detailed grade 3 and grade 4 clinical toxicities per patient during the trial

From: A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia

Patient no.

Dose (mg m−2)

Type of toxicity

Grade of toxicity

Details

DLT

UPN 7

3

Endocrinian

3

Diabetes

Yes

  

Infectious

3

Candidiasis septicaemia

No

UPN 10

5

Cardiovascular

3

Anasarque

Yes

  

Digestive

3

Haematemesis

Yes

UPN 12

5

Infectious

3

Pneumonia

No

UPN 15

5

Infectious

4

Aspergillosis

Yes

UPN 17

5

Cutaneous

3

Rash

Yes

UPN 19

5

Pain

3

Scalp

Yes

  1. DLT=dose-limiting toxicity.