Table 4 HHT Pharmacokinetic parameters
Dose | Cmax day 5 (ng ml−1) | T max day 5 (h) | Cmin day 5 (ng ml−1) | Cmin day 9 (ng ml−1) | AUC day 9 (ng h ml−1) | Vdβ/F (l kg−1) | CL/ F (l h−1) | T 1/2 (h) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
mg m −2 day −1 | mg | No. Pts | Mean | s.d. | Mean | s.d. | Mean | s.d. | Mean | s.d. | Mean | s.d. | Mean | s.d. | Mean | s.d. | Mean | s.d. |
0.5 | 0.9–1.0 | 3 | 10.5 | 8.8 | 1.0 | 0.12 | 3.4 | 0.9 | 169 | 38 | 1.52 | 0.39 | 5.9 | 1.60 | 13.4 | 3.8 | ||
3 | 4.8–5.4 | 2 | 78.0 | 18.2 | 0.6 | 0.53 | 27.4 | 27.9 | 14.7 | 8.3 | 441 | 291 | 2.54 | 0.75 | 14.2 | 8.77 | 8.9 | 3.7 |
5 | 7.0–10.0 | 12 | 96.1 | 20.3 | 0.6 | 0.43 | 31.3 | 16.7 | 25.6 | 20.3 | 909 | 550 | 2.02 | 1.43 | 11.6 | 10.4 | 10.8 | 3.2 |
Grand mean | 11.01 | 3.4* | ||||||||||||||||
