Table 5 Genotype frequencies and effect sizes for most significant two-way interaction with logistic regression

From: Interactions between genes involved in the antioxidant defence system and breast cancer risk

 

TRXR2-04

 

0

1

2

Total

TRX1-14

    

 0

362/441

700/622

291/292

1353/1355

 

1 (N/A)

0.73 (0.61–0.87)

0.82 (0.67–1.02)

1 (N/A)

 1

226/196

388/365

178/121

792/682

 

0.71 (0.56–0.90)

0.77 (0.63–0.94)

0.56 (0.43–0.73)

0.86 (0.76–0.98)

 2

37/37

57/66

19/34

113/137

 

0.82 (0.51–1.32)

0.95 (0.65–1.39)

1.47 (0.82–2.62)

1.21 (0.92–1.58)

Total

    
 

625/674

1145/1053

488/447

 
 

1 (N/A)

0.85 (0.74–0.98)

0.85 (0.72–1.01)

 
  1. Genotype frequencies and effect sizes for most significant two-way interaction with logistic regression. Loci: TRX1-14 and TRXR2-04. At each locus: 0=common homozygote, 1=heterozygote and 2=rare homozygote. In each cell: controls/cases; odds ratio (95% confidence interval). The log-likelihood ratio statistic is 14.77 (P=0.00026, 8 df).