Table 1 The number of LOHs detected in samples of ‘normal’ human breast tissue from two mastectomies and two prophylactic mastectomies

From: Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers

Sample no.

Specimen

No. of clones

No. of informative microsatellite markers

No. of LOH

% of clones with LOH

1

Mastectomy BRCA2

199

3

2 wt

1.005

2

Prophylactic BRCA1

197

6

2 wt

1.015

3

Mastectomy BRCA1

406

6

2 wt, 1 mut

0.739

4

Prophylactic BRCA1 (contralateral to sample 3)

190

6

1 wt, 1 mut, 1 non-BRCA1

1.579

  1. Wt=loss from wild-type allele, mut=loss from mutant allele.
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