Figure 1

Linear depiction of the HAdV-5 243R E1A protein. The regions conserved between serotypes are labelled as CR1, CR2 and CR4; amino-acid ordinates depict CR boundaries. The domains required for the indicated E1A functions are indicated as black bars beneath the map. The location and consensus sequences of binding motifs necessary for interaction with CBP/p300, pRb and CtBP are indicated, as are the general regions of E1A implicated in binding to the specified cellular proteins. K239, the major acetylation site targeted by CBP/p300, is also depicted.