Table 2 Dose escalation and DLTs

From: A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12 in Japanese patients with solid tumours

Dose (mg m−2)

Number of patients

DLTs ( n)

300

3

None

500

3

None

600

3

None

700

6

G3 ALT elevation (1)

800

3

None

900

4a

None

1000

3

None

1200

6

G3 infection (1); G3 rash (1)

  1. ALT=alanine transaminase; DLT=dose-limiting toxicity; G3=grade 3.
  2. aOne patient was excluded for DLT analysis because of grade 3 hyperglycemia at the beginning of the study.
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