Table 1 Clinicopathological data of 99 patients with MRCC
Characteristics | n | Median | % | Range |
|---|---|---|---|---|
No. of patients | 99 | |||
Sex | ||||
Male | 74 | 74.7 | ||
Female | 25 | 25.3 | ||
Age (years) | 65 | 34–83 | ||
KPS | ||||
100% | 69 | 69.7 | ||
90% | 18 | 18.2 | ||
⩽80% | 12 | 12.1 | ||
Histology | ||||
Clear cell | 85 | 85.9 | ||
Papillary | 12 | 12.1 | ||
Collecting duct | 2 | 2 | ||
T stage | ||||
pT1 | 15 | 15.2 | ||
pT2 | 12 | 12.1 | ||
pT3a | 44 | 44.4 | ||
pT3b | 28 | 28.3 | ||
Nuclear grade | ||||
G1 | 3 | 3 | ||
G2 | 30 | 30.3 | ||
G3 | 38 | 38.4 | ||
G4 | 18 | 18.2 | ||
Not available | 10 | 10.1 | ||
Nephrectomy | ||||
Yes | 92 | 92.9 | ||
No | 7 | 7.1 | ||
No. of metastatic sites | ||||
Local recurrence only | 3 | 3 | ||
1 site | 33 | 33.3 | ||
2 sites | 28 | 28.3 | ||
3 sites | 17 | 17.2 | ||
⩾4 sites | 18 | 18.2 | ||
Sites of metastatic disease | ||||
Lung | 62 | 61.4 | ||
Mediastinum | 19 | 18.8 | ||
Bone | 34 | 33.7 | ||
Liver | 23 | 22.8 | ||
Abdominal lymph nodes | 14 | 18.9 | ||
Pancreas | 2 | 2 | ||
Cerebral | 11 | 10.9 | ||
Surgery for metastases | ||||
No metastasectomy | 56 | 56.6 | ||
Metastasectomy | 43 | 43.4 | ||
Pulmonary | 11 | 11.1 | ||
Bone | 27 | 27.3 | ||
Local recurrence surgery | 5 | 5 | ||
CNS | 4 | 4 | ||
Pancreas | 1 | 1 | ||
Patients receiving metastasectomy twice | 5 | 5 | ||
Baseline laboratory parameters | ||||
Haemoglobin normal ⩾11.5 g/dl | 78 | 12.5 | 78.8 | 8.8–16.3 |
LDH normal <200 U/l | 68 | 176 | 68.7 | 26–2350 |
CRP normal <0.5 mg/dl | 23 | 2.1 | 23.2 | 0.5–195 |
aP normal 0–15 U/l | 53 | 111 | 53.5 | 47–819 |
Best response to outpatient immunotherapy | ||||
CR | 8 | 8.5 | ||
PR | 4 | 4.3 | ||
SD | 33 | 35.2 | ||
PD | 49 | 49.5 | ||
Not evaluable | 5 | 5.1 | ||
