Figure 2

Morphological characteristics of adipose tissue. (A) Haematoxylin and eosin stained sections of epididymal adipose tissue from control (a), pair-fed (b) and tumour-bearing (c) mice, by light microscopy. Note many shapeless and shrunken adipocytes are present in the tissue of a tumour-bearing mouse at day 18 after tumour inoculation. Morphometric analysis of perimeter (B) and sectional area (C) of adipocytes of epididymal adipose tissue from control, pair-fed and tumour-bearing mice. Values are mean ±s.e.m. for five animals per group. ^*P<0.05, ^**P<0.01 vs controls; ^††P<0.01 vs pair-fed. (D) Light microscopy of Sirius Red stained sections of epididymal adipose tissue from control (a), pair-fed (b) and tumour-bearing (c) mice at day 18 after tumour inoculation. Marked increase in collagen fibre staining is seen in the interstitial matrix of adipose tissue from tumour-bearing mice.