Table 3 Cox proportional hazard regression analysis of Six1 protein expression and clinicopathological parameters in relation to the overall survival of HCC patients

From: Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma

 

Univariable analysis

Multivariable analysis

 

HR (95% CI)

P

HR (95% CI)

P

Six1protein

 Positive vs negative

1.956 (1.011–3.784)

0.046

1.29 (0.624–2.503)

NS

pTNM stage

 Advanced vs early

4.952 (2.077–11.808)

0.000

7.698 (1.891–31.33)

0.004

Venous infiltration

 Presence vs absence

3.302 (1.572–6.934)

0.002

0.493 (0.136–1.780)

NS

AFP level

 >20 ng ml−1 vs ⩽20 ng ml−1

3.062 (1032–4.118)

0.04

1.735 (0.783–3.844)

NS

  1. AFP=alpha-fetoprotein; CI=confidence interval; HCC=hepatocellular carcinoma; HR=hazard ratio; pTNM=pathologic tumour-node-metastasis; NS=not significant.