Table 2 Clinical characteristics of patients with secondary metastases (n=46) and without SDD (n=224)
Patients with SDD | Patients without SDD | |||
|---|---|---|---|---|
Characteristics | n | % | n | % |
Gender | ||||
Male | 27 | 58.7 | 115 | 51.3 |
Female | 19 | 41.3 | 109 | 48.7 |
Median age at primary diagnosis | 10.2 years (0.1–19.1 years) | 9.2 years (0.1–21 years) | ||
Primary tumour site | ||||
Cerebral hemispheres | 14 | 30.4 | 53 | 23.7 |
Pons/brainstem | 14 | 30.4 | 106 | 47.3 |
Thalamus/basal ganglia | 6 | 13.0 | 24 | 10.7 |
Cerebellum | 5 | 10.9 | 5 | 2.2 |
Ventricles | 2 | 4.3 | 6 | 2.7 |
Medulla | 1 | 2.2 | 1 | 0.4 |
Pineal region | 1 | 2.2 | 1 | 0.4 |
Hypothalamus | 0 | 0 | 2 | 0.9 |
Spinal cord | 1 | 2.2 | 4 | 1.8 |
Gliomatosis cerebri | 2 | 4.3 | 11 | 4.9 |
Brain NOS | 0 | 0 | 11 | 4.9 |
Diagnosis | ||||
Glioblastoma multiforme grade IV | 20 | 43.5 | 76 | 33.9 |
Giant cell glioblastoma grade IV | 1 | 2.2 | 2 | 0.9 |
Anaplastic astrocytoma grade III | 17 | 37.0 | 63 | 28.1 |
Oligoastrocytoma/-dendroglioma grade III | 0 | 0 | 5 | 22.3 |
Gliosarcoma grade IV | 0 | 0 | 2 | 0.9 |
Astroblastoma/xantoastrocytoma grade III | 0 | 0 | 3 | 1.3 |
Astrocytoma WHO grade I/II (DIPG) | 2 | 4.3 | 16 | 7.1 |
DIPG, only radiologic diagnosis | 6 | 13.0 | 57 | 25.4 |
Spinal MRI at primary diagnosis | 10/39* | 25.6 | nd | |
CSF positive at primary diagnosis | 2/11* | 18.2 | 3/33 | 9.1 |
Resection of the primary tumour (n=222) | ||||
Complete resection | 7 | 15.2 | 33 | 14.9 |
Subtotal resection (⩾95% of the tumor removed) | 9 | 19.6 | 24 | 10.8 |
Partial resection (< 95% of the tumor removed) | 9 | 19.6 | 39 | 17.7 |
Biopsy | 15 | 32.6 | 75 | 33.8 |
No surgery | 6 | 13.0 | 51 | 22.9 |
Irradiation of the primary tumour (n=221) | ||||
Yes | 45 | 97.8 | 201 | 90.9 |
No | 1 | 2.2 | 20 | 9.1 |
Simultaneous radiochemotherapy of the primary tumor (n=220) | ||||
Yes | 21 | 45.7 | 95 | 43.2 |
No | 25 | 54.3 | 125 | 56.8 |
Chemotherapy of the primary tumour (n=221) | ||||
Yes | 42 | 91.3 | 204 | 92.3 |
No | 4 | 8.7 | 17 | 7.7 |
