Table a2 Multivariate model for prostate cancer death based on Gleason Grade (G), PSA (P), age (A), percentage cancer in biopsy(C), clinical stage (T), year (Y) and (a) initial hormone treatment (H), (b) In patients with no initial treatment, and (c) Patients with initial treatment by early hormone therapy

Variables	df	N	χ ²	Δ χ ² (1 df)
(a)
Total eligible cohort
G	1	1656	186.42	186.4
G Gm	2	2333	188.08
G Gm P	3	2333	272.10	84.0
G Gm P A	4	2333	287.34	15.2
G Gm P A (restricted – if C not missing)	4	1654	239.45
G Gm P A C (restricted – if C not missing)	5	1654	249.20	9.8
G Gm P A C Cm (restricted – if T not missing)	6	1751	231.37
G Gm P A C Cm T (restricted – if T not missing)	7	1751	239.34	8.0
G Gm P C Cm A T Tm	8	2333	305.12
G Gm P C Cm A T Tm Y	9	2333	307.96	2.8
G Gm P C Cm A T Tm Y H	10	2333	328.65	20.7
(b)
No initial treatment cohort
G	1	1176	100.53	100.5
G Gm	2	1663	104.07
G Gm P	3	1663	130.72	26.7
G Gm P A	4	1663	144.81	14.1
G Gm P A (restricted – if C not missing)	4	1177	117.64
G Gm P A C (restricted – if C not missing)	5	1177	126.47	8.8
G Gm P A C Cm (restricted – if T not missing)	6	1219	111.29
G Gm P A C Cm T (restricted – if T not missing)	7	1219	119.31	8.0
G Gm P C Cm A T Tm	8	1663	162.37
G Gm P C Cm A T Tm Y	9	1663	166.25	3.9
(c)
Initial treatment cohort
G	1	480	33.39	33.4
G Gm	2	670	33.14
G Gm P	3	670	50.67	17.5
G Gm P A	4	670	54.28	3.6
G Gm P A (restricted – if C not missing)	4	477	52.66
G Gm P A C (restricted – if C not missing)	5	477	52.85	0.2
G Gm P A C Cm (restricted – if T not missing)	6	532	46.11
G Gm P A C Cm T (restricted – if T not missing)	7	532	46.73	0.6
G Gm P C Cm A T Tm	8	670	55.34
G Gm P C Cm A T Tm Y	9	670	56.45	1.1

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