Table 2 Clinical parameters of patients with RT–PCR-negative and -positive PBSC collection in the whole study population and in the patients with indication of HDCT during primary treatment
HDCT (all indications) ( n =88) | HDCT (indication during primary treatment) ( n =65) | ||||
---|---|---|---|---|---|
RT–PCR PBSC collection | RT–PCR PBSC collection | ||||
Variable | Negative ( n =81) | Positive ( n =7) | Negative ( n =60) | Positive ( n =5) | P -value Fischer's exact test |
Initial metastases | |||||
Yes | 31 | 1 | 31 | 1 | NS |
No | 50 | 6 | 29 | 4 | |
Initial BM metastases | |||||
Yes | 11 | 0 | 11 | 0 | NS |
No | 70 | 7 | 49 | 5 | |
Initial BM micrometastases | |||||
Yes | 6 | 0 | 4 | 0 | NS |
No | 20 | 1 | 19 | 1 | |
NE | 55 | 6 | 37 | 4 | |
Initial circulating tumour cells | |||||
Yes | 2 | 1 | 1 | 1 | NS |
No | 20 | 0 | 18 | 0 | |
NE | 59 | 6 | 41 | 4 | |
Number of chemotherapy cycles before PBSC collection (median) | |||||
⩽5 cycles | 43 | 5 | 24 | 3 | NS |
>5 cycles | 38 | 2 | 36 | 2 | |
Metastases at the time of PBSC collection | |||||
Yes | 33 | 3 | 19 | 1 | NS |
No | 48 | 4 | 41 | 4 | |
Disease status at the time of PBSC collection | |||||
CR | 35 | 2 | 30 | 2 | NS |
No CR | 44 | 5 | 30 | 3 | |
NE | 2 | 0 | 0 | 0 | |
Indication of HDCT | |||||
Primary treatment | 60 | 5 | NS | ||
Relapse | 21 | 2 |