Table 2 Serum concentrations of acute phase proteins and cytokines for the patient group (n=56) and healthy controls (n=22)

From: Elevated tumour interleukin-1β is associated with systemic inflammation: a marker of reduced survival in gastro-oesophageal cancer

 

Patient group ( n =56)

Control group ( n =22)

P -value a

CRP (mg/l)

4 (2–16)

1 (1–3)

<0.001

Haptoglobin (mg/l)

1869 (1421–2651)

821 (627–1157)

<0.001

ACT (mg/l)

409 (326–502)

245 (213–261)

<0.001

Albumin (g/l)

42 (39–44)

42 (39–45)

0.227

Transferrin (mg/l)

2076 (1565–2648)

2197 (1861–2451)

0.478

IL-1β (pg/ml)

0b

0

—

IL-6 (pg/ml)

0 (0–91)

11 (0–214)

0.412

IL-8 (pg/ml)

0 (0–57)

0 (0–118)

0.683

IL-10 (pg/ml)

0c

0

—

sTNF-R (ng/ml)

2.6 (1.3–4.1)

2.8 (1.3–3.6)

0.559

  1. ACT=α1-antichymotrypsin; CRP=C-reactive protein; IL=interleukin; sTNF-R=soluble tumour necrosis factor receptor (p55).
  2. Positive acute phase protein concentrations were elevated in the patient group compared with the control group. There were no differences between concentrations of the negative acute phase reactants or serum cytokines.
  3. aMann–Whitney U-test.
  4. bOnly two patients had measurable serum IL-1β concentrations.
  5. cOnly four patients had measurable IL-10 concentrations. Values are median (interquartile range).
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