Table 2 Growth and drug resistance profile of ALL cell lines

From: Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines

Cell line

Phenotype

Specimen

DT (h)

ARA-C

6MP

6TG

MTX

DEX

MPRED

DNR

DOX

ASP

VCR

ALL-SIL

T-ALL

Relapse

64

0.0303

0.416

0.652

0.00649

11.620

137.31

0.00933

0.09500

0.00007

0.00020

CEM

T-ALL

Relapse

23

0.0939

1.240

0.613

0.00599

500

419.88

0.20400

0.42900

1.99695

0.00213

DU528

T-ALL

Diagnosis

40

0.0123

65.800

1.845

0.0101

500

190.16

0.05300

0.18800

0.00003

0.00308

HSB2

T-ALL

Diagnosis

40

0.0020

0.283

0.141

0.0055

2

276.98

0.00092

0.00072

0.04390

0.00013

JURKAT

T-ALL

Relapse

26

0.0153

0.410

0.334

0.00784

500

500

0.01400

0.03270

1.25424

0.00168

MOLT4

T-ALL

Relapse

33

0.0129

0.454

0.348

0.00671

500

356.04

0.00319

0.01360

0.09690

0.00078

PER-117

T-ALL

Relapse

56

0.0059

0.042

0.049

0.00539

32.440

85.71

0.00435

0.01100

0.03022

0.00022

PER-255

T-ALL

Diagnosis

66

0.0033

0.223

0.060

0.00683

0.003

0.05

0.00163

0.00475

0.00004

0.00016

PER-427

T-ALL

Diagnosis

209

0.2810

22.500

50.800

0.00702

51.990

0.19

0.01110

0.05460

0.43701

0.00493

PER-487

T-ALL

Diagnosis

363

0.0264

15.100

3.175

0.0111

189.080

14.45

0.01060

0.05410

0.00008

0.00141

PER-537

T-ALL

Diagnosis

223

0.0172

22

1.072

0.0339

167.020

9.86

0.00325

0.01340

0.00016

0.00036

PER-550

T-ALL

Relapse

252

0.0030

3.550

0.440

0.0333

0.002

0.02

0.00163

0.00956

0.00003

0.00025

PER-604

T-ALL

Relapse

181

0.0059

16

1.572

0.0866

0.117

0.17

0.00428

0.03610

0.00003

0.00080

PER-606

T-ALL

Relapse

442

0.0008

8.460

0.758

0.0678

0.001

0.02

0.00216

0.00762

0.00003

0.00017

PER-608

T-ALL

Diagnosis

260

0.0073

6.670

0.142

0.0123

0.003

0.06

0.00128

0.00405

0.00004

0.00033

   

Median

0.0123

3.550

0.613

0.0078

32.440

14.45

0.00430

0.01360

0.00010

0.00040

PER-145

Pre-B-ALL

Relapse

108

0.0572

173.965

10.940

725.1374

500

84.75

0.04880

0.05436

0.00007

0.00161

PER-278

Pre-B-ALL

Diagnosis

104

0.0073

47.754

1.795

0.00929

0.072

1.08

0.00245

0.00904

0.28644

0.00080

PER-371

Pre-B-ALL

Diagnosis

69

0.0040

39.708

71.600

0.01466

0.003

0.06

0.00600

0.01174

0.95612

0.00089

PER-377

B-ALL

Relapse

66

0.0211

0.829

0.360

0.00546

0.0329

26.13

0.01230

0.08807

1.20029

0.01150

PER-490

Infant Pre-B-ALL

Diagnosis

97

0.0279

97.495

3.200

0.00602

0.002

0.01

0.00669

0.02071

0.00003

0.00073

PER-495

B-ALL

Relapse

53

0.0034

0.080

0.037

0.00637

304.170

180.12

0.00419

0.01045

0.01631

0.00059

PER-485

Infant Pre-B-ALL

Relapse

53

2.5000

0.321

0.338

0.00245

500

500

0.00358

0.15423

0.19488

0.00030

   

Median

0.0211

39.7077

1.7950

0.0064

0.0719

26.1250

0.0060

0.0207

0.1949

0.0008

PER-607

EBV

Diagnosis

216

0.9992

62.198

13.580

0.01312

307

301.46

0.01110

0.07281

0.31872

0.00230

  1. ALL=acute lymphoblastic leukaemia; ARA-C=cytosine arabinoside; ASP=L-asparaginase; DEX=dexamethasone; DNR=daunorubicin; DOX=doxorubicin; DT=doubling time; EBV=Epstein–Barr virus-transformed cell line; 6MP=6-mercaptopurine; MTX=methotrexate; 6TG=6-thioguanine; MPRED=methylprednisolone; VCR=vincristine.
  2. IC50 units are μg ml−1, except for ASP (IU ml−1).
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