Table 3 Details of ex vivo resistance studies used for comparison with in vitro data

From: Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines

Drug

No. of studies

No. of diagnosis specimens

No. of relapse specimens

Total No. of specimens

References

DEX

7

737

248

985

1, 2, 5, 8, 9, 11, 13

MPRED

1

13

6

19

9

VCR

9

1137

275

1412

1, 2, 5–8, 11–13

ARA-C

9

995

331

1326

1–3, 5, 8, 10–13

6MP

5

764

220

984

1, 2, 5, 8, 11

6TG

9

973

291

1264

1–3, 5, 7, 8, 11–13

DNR

8

1126

278

1404

1, 2, 5, 7, 8, 11–13

DOX

5

580

257

837

1, 2, 5, 8, 11

ASP

7

1013

275

1288

1, 2, 4, 5, 8, 11–12

  1. ARA-C=cytosine arabinoside; ASP=L-asparaginase; DEX=dexamethasone; DNR=daunorubicin; DOX=doxorubicin; 6MP=6-mercaptopurine; 6TG=6-thioguanine; MPRED=methylprednisolone; VCR=vincristine.
  2. References: (1) Klumper et al (1995); (2) Pieters et al (1998); (3) Duyn et al (1999); (4) Fine et al (2005); (5) Kaspers et al (2005); (6) Mihal et al (2004); (7) Pieters et al (1991); (8) Styczynski et al (2000); (9) Styczynski et al (2002); (10) Styczynski et al (2005); (11) Zwaan et al (2000); (12) Pieters et al (1990); (13) Steinbach et al (2005).
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