Table 1 Response in BN-175 soft tissue sarcoma-bearing rats after doxorubicin-based ILP in combination with Histamine over a total period of 08 days

From: Histamine, a vasoactive agent with vascular disrupting potential, improves tumour response by enhancing local drug delivery

Treatment a

CR b

PR (%)

NC (%)

PD (%)

Sham (n=5)

—

—

—

100

DXR (n=6)

—

—

—

100

Histamine (n=7)

—

—

29

71

Hi+DXR (n=6)

—

17

50

33

  1. aDoxorubicin (DXR, 400 μg) and Histamine (Hi, 1000 μg) were added as boluses to the perfusate (5 ml).
  2. bResponses were scored as described in Materials and Methods. CR=complete response; PR=partial response; NC=no change; PD=progressive disease.
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