Table 2 Results of the MSI analysis in MSH6, MLH1 and MSH2 mutation carriers

From: Very low prevalence of germline MSH6 mutations in hereditary non-polyposis colorectal cancer suspected patients with colorectal cancer without microsatellite instability

MSI pattern

MSH6 mutation carriers

MLH1 and MSH2 mutation carriers

P -value Fisher exact

One or more of three dinucleotides a stable

CRC

4/5 (80%)

4/22 (18%)

0.017

Non CRC

4/5 (80%)

1/6 (17%)

NS

One or more mononucleotides b stable

 CRC only

1/5 (20%)

2/26 (8%)

NS

 Non CRC

0/5 (0%)

0/6 (0%)

NS

  1. NS=not significant; CRC=colorectal cancer; MSI=microsatellite instability.
  2. aD2S123, D5S346, and D17S250.
  3. bBAT25 and BAT26.
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