Table 2 Reported toxicity profile during the first course of seliciclib treatment
Seliciclib 100 mg b.i.d | Seliciclib 200 mg b.i.d | Seliciclib 800 mg b.i.d | |
|---|---|---|---|
No. of subjects | 3 | 6 | 12 |
No. with grade 3 & 4 adverse events | 0 | 2 | 7 |
γ GT increase | 0 | 1 | 3 |
Hypokalemia | 0 | 0 | 3 |
Hyperglycaemia | 0 | 0 | 1 |
Hyponatraemia | 0 | 0 | 1 |
Rash | 0 | 0 | 1 |
Hypotension | 0 | 0 | 1 |
Lymphopenia | 0 | 0 | 1 |
Anorexia | 0 | 0 | 1 |
Fatigue | 0 | 0 | 1 |
ALT increased | 0 | 1 | 0 |
AST increased | 0 | 1 | 0 |
Alk Phos increase | 0 | 1 | 0 |
Bilirubin increase | 0 | 1 | 0 |
CKMB increase | 0 | 1 | 0 |
