Table 4 Summary of Seliciclib pharmacokinetics during course 1

	Dose		C_max (ng ml⁻¹)	T _max (min)	t _1/2 (min)	AUC_last (min ng ml⁻¹)	AUC_inf (min ng ml⁻¹)
Day 1	100 mg (n=3)	Mean	248	112	267	112236	115384
		%CV	91	101	55	58	56
		Median	134	61	278	82403	90289
	200 mg (n=6)	Mean	179	279	176	165949	181877
		%CV	123	95	42	62	59
		Median	80	167	149	185025	230597
	800 mg (n=12)	Mean	3197	177	219	3163604	3177921
		%CV	42	68	21	43	43
		Median	3161	120	232	3441798	3452569
Day 7	100 mg (n=3)	Mean	162	190	268	171555	173422
		%CV	15	46	24	36	35
		Median	152	240	234	181815	182620
	200 mg (n=6)	Mean	310	62	781	175903	255297
		%CV	43	71	173	59	89
		Median	303	60	228	184620	208748
	800 mg (n=8)	Mean	2774	99	230	1590950	1598426
		%CV	71	26	43	69	69
		Median	2636	107	209	1275901	1278974

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