Table 1 Dosea escalation cohorts

From: Concurrent irinotecan, oxaliplatin and UFT in first-line treatment of metastatic colorectal cancer: a Phase I study

Cohort

UFT (mg m−2 day−1)

Irinotecan (mg m−2 day−1)

Oxaliplatin (mg m−2 day−1)

1

200

180

85

2

250

180

85

3

250

180

100

4

300

180

100

  1. Doses were calculated using the patient's body surface area with no upper limit. UFT was administered on days 1–21 of the 28-day cycle; irinotecan was administered on day 1 and oxaliplatin was administered on day 15.
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