Table 5 Worst toxicity per patient (all cycles) by dose level

From: Concurrent irinotecan, oxaliplatin and UFT in first-line treatment of metastatic colorectal cancer: a Phase I study

Dose level

1 ( n =6)

2 ( n =6)

3 ( n =9)

4 ( n =4)

NCI-CTC grade

2

3

4

2

3

4

2

3

4

2

3

4

Anaemia

1

  

1

  

2

  

1

  

Leucopaenia

  

1

      

2

  

Neutropaenia

  

1

1

     

1

  

Thrombocytopaenia

 

1

          

Alopecia

          

1

 

Anorexia

1

           

Lethargy

2

1

 

2

  

4

  

2

1

 

Nausea

1

1

 

1

  

1

   

1

 

Vomiting

1

1

 

1

  

1

   

1

 

Diarrhoea

2

2

 

3

1

  

1

 

1

3

 

AST

2

           

Neuropathy

       

1

    

Infection

  

1

         

Abdominal pain

 

1

        

1

 

Cardiac

  

1

         
  1. AST=aspartate aminotransferase; NCI-CTC=National Cancer Institute Common Toxicity Criteria.
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