Table 6 Number of cycles given, number of dose reductions and delays

From: Concurrent irinotecan, oxaliplatin and UFT in first-line treatment of metastatic colorectal cancer: a Phase I study

  

Irinotecan cycles

Oxaliplatin cycles

UFT cycles

 

Dose level

No. of patients

Total

Median (range)

20% DR

50% DR

Total

Median (range)

20% DR

50% DR

Total

Median (range)

1 capsule DR a

2 capsules DR a

Delays Weeks

1

6

22

3 (1–6)

4

0

17

2 (0–6)

0

0

22

3 (1–6)

3

0

3

2

6

27

6 (1–6)

13

0

23

4 (1–6)

2

0

27

6 (1–6)

10

0

5

3

9

46

6 (1–6)

2

0

43

6 (0–6)

3

0

46

6 (1–6)

3

0

4

4

4

18

5.5 (1–6)

11

1

11

3 (0–5)

2

0

18

5.5 (1–6)

11

1

3

Total

25

113

—

30

1

94

—

7

0

113

—

27

1

15

  1. aEach UFT capsule contained tegafur 100 mg and uracil 224 mg.
  2. DR: dose reduction.
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