Figure 2
From: ASPP: a new family of oncogenes and tumour suppressor genes
Regulation of ASPP family of proteins. Stress signals including DNA damage, upregulation of the E2F transcription factors and inhibition of the proteasome activate ASPP1 and ASPP2 to interact with p53 family members and induce apoptosis. iASPP prevents this, instead allowing cell proliferation to occur. Gene silencing of ASPP1 and ASPP2 by methylation also prevents p53-dependent apoptosis.
