Figure 3
Synergy analysis of OHP combined with TFT for the colorectal cancer cell lines. Interpretation of CI values: CI<0.9 means synergism; CI=0.9–1.1 means additive; CI>1.1 means antagonism. TFTc: combination of the drugs in which TFT was kept at a constant concentration (IC25); OHPc: combination of the drugs in which OHP was kept at a constant concentration (IC25); 1:1 ratio: the two drugs were added in a fixed 1:1 IC50-based molar ratio. A mean CI was calculated from data points with FA>0.5 for the combinations with variable drug ratio, and from the FA values 0.6, 0.75, 0.9 for the fixed ratio combinations. Values (mean CI±s.e.m.) are based on 3–4 separate experiments. See also Materials and Methods.
