Figure 2

Inflammatory cytokines enhance u-PA activity in a time (A) and dose (B)-dependent manner. Pretreatment with WXC-340 impaired baseline and cytokine-enhanced u-PA activity. Results are expressed as the mean±s.d. and are representative of four separate experiments, conducted in triplicate. Statistical significance was compared with control cells incubated with culture medium alone (*P<0.05).