Figure 4 | British Journal of Cancer

Figure 4

From: Inhibition of urokinase plasminogen activator with a novel enzyme inhibitor, wxc-340, ameliorates endotoxin and surgery-accelerated growth of murine metastases

Figure 4

Cytokine stimulation with TNF-α and IL-6 (2.5 ng ml−1) significantly enhances CT-26 in vitro ECmatrix invasion. This cytokine-mediated increased invasion is inhibited by the novel u-PA inhibitor WXC-340 at a concentration of 0.3 mg ml−1. Results are expressed as the mean±s.d. and are representative of four separate experiments, conducted in triplicate. Statistical significance was compared with control cells incubated with culture medium alone (*P<0.05) or cytokine stimulated cells (**P<0.05).

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