Table 2 Comparison of population pharmacokinetic parameter estimates for various models; coefficient of variation (%) shown in paranthesis

From: Pharmacokinetics and metabolism of 13-cis-retinoic acid (isotretinoin) in children with high-risk neuroblastoma – a study of the United Kingdom Children's Cancer Study Group

Model

OFV

CL/F

Ka

V/F

LAG/MTT

NN

D

Zero-order absorption with lag time

50.1

10.53 (89.4)

—

111.1 (100.0)

27.39 (44.7)

—

57.40 (70.7)

First-order absorption with lag time

24.3

15.40 (63.8)

0.050 (236)

64.07 (102)

53.52 (11.7)

—

—

Modified zero-order absorption with lag time

13.8

15.87 (68.6)

0.068 (154)

84.77 (92.1)

40.04 (27.2)

—

11.8 (200.0)

Transit model

18.5

15.55 (63.9)

0.054 (207)

72.24 (93.5)

57.40 (52.2)

20.09 (36.2)

—

  1. OFV, objective function value; CL/F, apparent clearance (l h−1); Ka, absorption rate (1 min−1); V/F, apparent volume of distribution (l); LAG, absorption lag time (min); MTT, mean time to absorption transition (min); NN, number of transit compartments; D, absorption duration (min).
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