Table 4 Summary statistics for 13-cisRA Cmax and 4-oxo-13-cisRA Cmax on study day 1 and 14, analysed by course

From: Pharmacokinetics and metabolism of 13-cis-retinoic acid (isotretinoin) in children with high-risk neuroblastoma – a study of the United Kingdom Children's Cancer Study Group

Parameter

Course

N

Mean

s.d.

13-cisRA

Day 1 (μ M)

2

27

2.78

2.31

 

4

13

5.43

2.23

 

6

10

3.25

1.99

Day 14 (μ M)

2

27

2.83

1.44

 

4

13

4.71

2.40

 

6

10

2.52

1.85

4-oxo-13-cisRA

Day 1 (μ M)

2

27

1.30

1.21

 

4

13

1.84

0.85

 

6

10

1.31

0.74

Day 14 (μ M)

2

27

4.67

3.17

 

4

13

6.43

4.11

 

6

10

3.49

1.98

  1. Abbrevitions: RA=retinoic acid; s.d.=standard deviation.
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