Figure 1

Aryl hydrocarbon receptor interacting protein germline change R16H found in two CRC samples. Here, the MSS sample is depicted as example. (A) Exon 1 wild-type sequence, shown for comparison. (B) R16H detected in the tumour sample. (C) R16H detected in the respective normal sample. Loss-of-heterozygosity was not observed in either of the cases with the R16H variant. The mutated base 47G>A is indicated by an arrow.