Table 5 Survival of 5-FU refractory pts treated with either O or I in clinical trials

From: Treatment of 5-fluorouracil refractory metastatic colorectal cancer: an Australian population-based analysis

 

Overall survival

 

6-month (%)

12-month (%)

Median (months)

 

Study

I

O

I

O

I

O

P-value

Second-line

 (Fuchs et al, 2003)

70

’

41

’

9.9

’

 

 (Maughan, 2005)

80

83

57

60

14.8

15.2

NS

 (Haller et al, 2004)

73

82 (I+O)

48

57 (I+O)

11.1

13.4 (I+O)

0.0072

Third-line

 (Rowland et al, 2005)

71

75

35

39

8.7

10

NS

  1. I, irinotecan; NS: nonsignificant; O, oxaliplatin.
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