British Journal of Cancer

Table 2 Carboplatin doses and estimated renal function-based dosing AUC vs actual AUC following pharmacologically guided dosing

From: Adaptive dosing and platinum–DNA adduct formation in children receiving high-dose carboplatin for the treatment of solid tumours

							Estimated		Achieved
Study	Patient	GFR (ml min⁻¹)	Target AUC (mg ml ⁻¹ . min)	Dose modification	Estimated total dose (mg) ^a	Actual total dose (mg)	AUC ^b (mg ml ⁻¹ .min)	% target AUC	AUC (mg ml ⁻¹ .min)	% Target AUC
MMT 98	1	110	20	Day 3	2610	1653	30.3	152	19.6	98
	2	115	20	Day 3	2720	2921	18.7	94	ND	ND
	3	104	20	Day 3	2350	1450	32.0	160	19.8	99
	4	158	20	Day 2	3660	2868	32.6	163	25.2	126
	5	85	20	None	2090	2090	20.7	104	20.7	104
	6	71	20	None	1750	1750	21.5	108	ND	ND
	7	73	20	Day 4	1900	2860	15.4	77	23.7	119
	8	90	20	Day 4	1565	1243	23.8	119	19.0	95
	9	21	20	Day 3	575	508	22.5	113	ND	ND
	10	228	20	Day 3	4785	4071	23.5	118	ND	ND
	11	30	20	Day 3	750	970	16.9	85	22.1	111
	12	56	20	Days 3/5	1350	1790	14.8	74	19.3	97
	13	59	20	Days 3/5	1475	1575	17.9	90	19.5	98
	14	62	20	Day 4	1500	2500	13.0	65	22.6	113
	15	97	20	Day 4	2160	2696	15.0	75	18.8	94
	16	101	20	Day 4	2650	4070	13.0	65	ND	ND
	17	145	20	Day 4	3400	2664	26.5	133	20.1	101
PNET	18	34	21	None	1026	1026	15.3	73	ND	ND
	19	104	21	Day 3	3720	2830	27.6	131	ND	ND
	20	74	21	None	1590	1590	16.7	80	16.7	80
	21	97	21	Day 3	3141	2554	25.8	123	ND	ND
	22	124	21	Day 3	3258	2387	30.7	146	20.7	99
	23	32	21	Day 3	900	1130	14.5	69	19.0	90
	24	128	21	Day 3	4320	2880	44.7	213	ND	ND
	25	74	21	None	1608	1608	21.0	100	21.0	100
	26	42	21	None	1020	1020	20.1	96	20.1	96
	27	94	21	Day 3	3000	2360	26.7	127	ND	ND
	28	40	21	None	870	870	20.2	96	20.2	96
					Range:	MMT 98	13.0–32.6	65–163	18.8–25.2	94–126
						PNET	14.5–44.7	69-213	16.7–21.0	80–100

^aEstimated total dose is based on the day 1 renal function-based dose without modification.
^bEstimated total AUC is that which would have resulted if no dose adjustment had been made (based on daily carboplatin clearance values)

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