Table 3 Platinum–DNA adduct levels determined in patients following carboplatin administration on days 1 and 5 of treatment in four patients on the MMT 98 protocol
Patient | Study day | Carboplatin dose (mg) | Carboplatin AUC (mg ml −1 .min) | Pt-DNA adducts (nmol g −1 DNA) |
|---|---|---|---|---|
1 | 1 | 522 | 5.2 | 2.28 |
5 | 203 | 1.9 | 6.99 | |
2 | 1 | 380 | 2.5 | 0.24 |
5 | 860 | 7.8 | 2.21 | |
3 | 1 | 732 | 5.1 | 0.59 |
5 | 534 | 5.8 | 4.06 | |
4 | 1 | 418 | 3.8 | 0.57 |
5 | 418 | 4.2 | 3.21 |
