Table 2 Patients characteristics at time of relapse or refractory disease

From: A comparison of patients with relapsed and chemo-refractory gestational trophoblastic neoplasia

 

Patients with relapsed disease

Patients with refractory disease

Number

60

11

Median time to relapse or refractory disease (months)

4 months (range 0.25–37 months)

3 months (range 0.25–6.75)

Median hCG at relapse/refractory disease

309 (range 25–105 000)

1244 (range 14–255 000)

Rate of hCG rise (median doubling time in days)

9 days (range 3–28) days)

NA

Median time between diagnosis of relapse and starting treatment (months)

0.4 months (range 0–3)

NA

Symptoms/method of diagnosis of relapse

hCG Screening 47

PV bleeding 2

Amenorrhoea 7

Othera 4

Screening 11

Site of disease at relapse

hCG relapse12

Mass in uterus only 29

Lung 12

Lung and uterus 3

Pelvis 1 other and uterus 3b

Unknown 1

NA

  1. HCG=human chorionic gonadotropin; NA=not available.
  2. aRespiratory symptoms, haemoptysis and re-entry to screening programme.
  3. bIncludes liver (1), liver and brain(1), pelvis (2).