Table 2 Association of EGFR expression and clinicopathological features

From: A simple and reproducible scoring system for EGFR in colorectal cancer: application to prognosis and prediction of response to preoperative brachytherapy

 

Cutoff

Below cutoff N (%)

Above cutoff N (%)

P -value

Predicting CR

 CR

18%

6 (14.6)

21 (51.2)

<0.001

 PR or NR

 

35 (85.4)

20 (48.8)

 

Predicting CR or PR

 CR or PR

15%

20 (51.3)

34 (79.1)

0.008

NR

 

19 (48.7)

9 (20.9)

 

T stage

 Early (T1+T2)

85%

118 (24.1)

14 (15.4)

0.069

 Late (T3+T4)

 

372 (75.9)

77 (84.6)

 

N stage

 N0

75%

244 (52.4)

54 (50.9)

0.792

 >N0

 

222 (47.6)

52 (49.1)

 

Tumour grade

 G1+G2

82%

431 (87.8)

89 (94.7)

0.051

 G3

 

60 (12.2)

5 (5.3)

 

Vascular invasion

Presence

80%

133 (27.6)

30 (29.1)

0.753

Absence

 

349 (72.4)

73 (70.9)

 

10-year survival

 Median (95% CI) (months)

85%

87.0 (69.0–103.0)

35.0 (23.0–58.0)

<0.001

  1. CR=complete response, PR=partial response.
  2. Cutoff scores were obtained by ROC curve analysis performed on the average EGFR scores.