Table 1 Light fluences (J cm−2) and corresponding irradiation times (s) inducing the same level of photocytotoxicity in MCF-7 cells under 3 and 24 h incubation with Foscan®

From: Relationship between subcellular localisation of Foscan® and caspase activation in photosensitised MCF-7 cells

 

Fluence, J cm −2 (irradiation time, s)

Photocytotoxicity a , b

3 h

24 h

63% (±17.1)

0.06 (30)

0.011 (5)

85% (±8.8)

0.13 (60)

0.021 (10)

93% (±6.3)

0.38 (180)

0.032 (20)

97% (±2.2)

0.74 (330)

0.064 (30)

  1. aPhotocytotoxicity of Foscan® was assessed in vitro using clonogenic assay. Cells were incubated with 1.5 × 10−6 M Foscan® for 3 or 24 h before irradiation with light doses producing 63 (LD63), 85 (LD85), 93 (LD93) and 97 (LD97) cell mortality.
  2. bMean±s.d. (in italic) of at least triplicate experiments.
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